Science alerts social network view all agriculture biology environment forestry geography health cancer/testis antigen cage exerts negative regulation on p53 expression through hdac2 and confers resistance to anti-cancer drugs submitted by mojedh7 2 years and 1 month ago the role of the cancer/testis antigen cage in drug resistance was investigated. The drug-resistant human melanoma malme3m (malme3mr) and the human hepatic cancer cell line snu387 (snu387r) showed in vivo drug resistance and cage induction. Induction of cage resulted from decreased expression and thereby displacement of dna methyltransferase 1(dnmt1) from cage promoter sequences. Various drugs induce expression of cage by decreasing expression of dnmt1, and hypomethylation of cage was correlated with the increased expression of cage. Down-regulation of cage in these cell lines decreased invasion and enhanced drug sensitivity resulting from increased apoptosis. Down-regulation of cage also led to decreased anchorage-independent growth. Down-regulation of cage led to increased expression of p53, suggesting that cage may act as a negative regulator of p53. Down-regulation of p53 enhanced resistance to drugs and prevented drugs from exerting apoptotic effects. In snu387r cells, cage induced the interaction between histone deacetylase 2 (hdac2) and snail, which exerted a negative effect on p53 expression. Chromatin immunoprecipitation assay showed that cage, through interaction with hdac2, exerted a negative effect on p53 expression in malme3mr cells. These results suggest that cage confers drug resistance by regulating expression of p53 through hdac2. buy viagracheapest generic viagra onlinebuy generic viagra online cheapviagra for salecheap generic viagracheap generic viagrawhere can i buy viagra onlinegeneric viagra onlinebuy viagra onlinecheap viagra Taken together, these results show the potential value of cage as a target for the development of cancer therapeutics. Topic: biology comments (0) who dugg this story? Email this link add your comment please login or signup to leave a comment related stories role for class i histone deacetylases in multidrug resistance submitted by daagdowiso 10 months ago - topic: biology recent reports have showed that histone deacetylase (hdac) inhibitor resulted in multidrug resistance (mdr) to other chemotherapeutic agents. However, the molecular mechanisms of class i hdacs on mdr regulation are poorly understood. In this study, hdac1 and hdac2 acted as enhancers to intensify... A major role of p95/611-ctf, a carboxy-terminal fragment of her2, in the down-modulation of the estrogen receptor in her2-positive breast cancers submitted by hado 1 year and 11 months ago - topic: health current classification of breast cancers depends in great part on the expression of human epidermal growth factor receptor 2 (her2), a cell surface tyrosine kinase receptor, and estrogen receptor (er), the nuclear receptor for estrogen. In addition to reliable biomarkers, these receptors are targ... The cancer/testis antige. I have just self-published my first novel: “A Way About” on Amazon.com.
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